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目的研究淄博地区健康妊娠期女性D-二聚体水平变化特点,建立适合该地区健康妊娠期女性D-二聚体的参考区间。方法选取2013年1月-2014年12月在淄博市中心医院体检的健康妊娠期女性1 388例和健康非妊娠期女性320例(作为健康对照组)。将健康妊娠期女性按照妊娠周期分为5组:1妊娠早期组(孕周≤13周组)270例;2妊娠中期Ⅰ组(孕周14~20周组)260例;3妊娠中期Ⅱ组(孕周21~27周组)290例;4妊娠晚期Ⅰ组(孕周28~34周组)294例;5妊娠晚期Ⅱ组(孕周≥35周组)274例。将上述5组和健康对照组按照年龄分为<35岁组和≥35岁组。空腹采集肘静脉血2.0 ml置于蓝帽凝血真空管,采用日本Sysmex CA 7000全自动血凝分析仪检测D-二聚体水平。结果妊娠期女性血浆D-二聚体水平随着妊娠周期的增加而升高;不同年龄段的健康对照组及不同妊娠周期的血浆D-二聚体水平差异有统计学意义(H值分别为241.53和129.85,P<0.01);同一妊娠周期不同年龄段D-二聚体水平差异无统计学意义(U值分别为1 597、1 622.5、20748、2 015.5、1 965,P>0.05);孕周≤13周、孕周14~20周、孕周21~27周、孕周28~34周及孕周≥35周的血浆D-二聚体参考区间分别为≤0.68 mg/L、≤1.37 mg/L、≤2.51 mg/L、≤3.07 mg/L、≤3.15 mg/L。结论该研究初步建立了淄博地区健康妊娠期女性血浆D-二聚体参考区间,为临床诊断及治疗提供了实验室依据。
Objective To study the characteristics of D-dimer levels in healthy pregnant women in Zibo area and to establish a reference interval suitable for D-dimer in healthy pregnant women in Zibo area. Methods From January 2013 to December 2014, 1 388 healthy pregnant women and 320 healthy healthy non-pregnant women were examined in Zibo Central Hospital as healthy control group. The healthy pregnant women were divided into 5 groups according to the gestation cycle: 1 The first trimester of pregnancy (gestational age ≤13 weeks group) 270 cases; 2 second trimester group Ⅰ (gestational age 14 to 20 weeks group) 260 cases; third trimester of pregnancy group Ⅱ (Gestational weeks 21-27 weeks group) 290 cases; 4 late pregnancy group Ⅰ (gestational weeks 28-34 weeks group) 294 cases; 5 late pregnancy Ⅱ group (gestational age ≥ 35 weeks group) 274 cases. The above five groups and healthy control group were divided into <35 years old group and> 35 years old group according to their age. Fasting blood samples were collected elbow venous 2.0 ml blue cap coagulation tube, the Japanese Sysmex CA 7000 automatic coagulation analyzer D-dimer level. Results The level of plasma D-dimer in pregnant women increased with the increase of gestation period. There were significant differences in plasma D-dimer levels between healthy control group and different pregnancy stages in different age groups (H values were 241.53 and 129.85, respectively, P <0.01). There was no significant difference in D-dimer levels at different ages in the same pregnancy (U values were 1 597,1 622.5,20748,2 015.5,1 965, P> 0.05). The reference intervals for plasma D-dimer at gestational weeks ≤13 weeks, gestational weeks14-20 weeks, gestational weeks21-27, gestational weeks 28-34, and gestational weeks ≥35 weeks were ≤0.68 mg / L, ≤ 1.37 mg / L, ≤2.51 mg / L, ≤3.07 mg / L, ≤3.15 mg / L. Conclusion The study initially established a reference interval of plasma D-dimer in healthy pregnant women in Zibo area, which provided a laboratory basis for clinical diagnosis and treatment.