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环孢多肽(Cyclosporine)最初用于预防器官移植的排斥反应,后来又用于各种皮肤病和自体免疫病等。将病人分两组。组1为21例牛皮癣患者,口服环孢多肽每日14 mg/kg,4周;组2为28例各种皮肤病患者,口服环孢多肽每日6 mg/kg,1～3个月。两组患者治疗前肾功能和血压均正常。环孢多肽治疗4周后,组1和2肾功能均呈进行性下降。血清尿素氮(SUN)分别增加100％(P<0.001)和25％(P<0.001),血清肌酐分别增加25％(P<0.05)和9％(P<0.05);肾功能分别在停服环孢多肽2
Cyclosporine was originally used to prevent rejection of organ transplants and was later used in various dermatological and autoimmune diseases. The patients were divided into two groups. Group 1 was 21 patients with psoriasis, oral cyclosporine daily 14 mg / kg, 4 weeks; group 2 28 patients with various skin diseases, oral cyclosporin daily 6 mg / kg, 1 to 3 months. Two groups of patients before treatment renal function and blood pressure were normal. Cyclosporine treatment for 4 weeks, group 1 and 2 showed a progressive decline in renal function. Serum urea nitrogen increased by 100% (P <0.001) and 25% (P <0.001), serum creatinine increased by 25% (P <0.05) and 9% Cyclosporin 2