目的：评价ｍｄｒ１基因与Ｐｇｐ糖蛋白在急性血病（ＡＬ）细胞中表达的相关性及其临床意义。方法：分别应用ＲＴＰＣＲ及流式细胞术（ＦＣＭ）检测３２例ＡＬ患者白血病细胞中的ｍｄｒ１ｍＲＮＡ及Ｐｇｐ糖蛋白表达率及表达水平，同时检测１４例正常人作为对照。结果：临床非耐药组ｍｄｒ１阳性率为２２．２％，Ｐｇｐ阳性率为３３．３％，而临床耐药组两者分别为７８．６％、８５．７％，均与临床治疗结果有极显著的一致性（Ｐ＜０．００５和Ｐ＜０．０１）。ｍｄｒ１＋／Ｐｇｐ＋的１３例患者中，１１例为临床耐药（８４．６％），其中１０例表现为ｍｄｒ１＋／Ｐｇｐ＋结果为中高度表达，临床非耐药的２例患者，ｍｄｒ１＋／Ｐｇｐ＋都是低度表达。相关性检验显示两方法有极显著的一致性。结论：ｍｄｒ１与Ｐｇｐ均可预测ＭＤＲ，同时检测ｍｄｒ１／Ｐｇｐ可提高ＭＤＲ检出符合率。 Objective: To evaluate the correlation between mdr1 gene and Pgp glycoprotein expression in acute blood disease (AL) cells and its clinical significance. Methods: RT PCR and flow cytometry (FCM) were used to detect the expression and expression of mdr1 mRNA and Pgp glycoprotein in 32 leukemia cells from AL patients. Simultaneously, 14 normal controls were used as controls. Results: The positive rate of mdr1 in clinical non-resistance group was 22.2%, and the positive rate of Pgp was 33.3%. The resistance rate in clinical drug resistance group was 78.6% and 85.7%, respectively. The clinical treatment results had extremely significant agreement (P<0.005 and P<0.01). Of the 13 patients with mdr-1+/P-gp+, 11 were clinically resistant (84.6%), and 10 of them showed moderate to high expression of mdr-1+/P-gp+, and 2 were non-drug resistant clinically. In patients, mdr1+/pgp+ were low expression. The correlation test showed a very significant agreement between the two methods. Conclusion: Both mdr1 and Pgp can predict MDR, and detection of mdr1/Pgp can increase the coincidence rate of MDR detection.