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目的制备医用羟基磷灰石( HA)纳米粒并观测其纳米结构及纳米尺寸效应;方法采用常态表面活性剂( 水包油)制备 HA 纳米粒,用电子显微镜、X 射线仪、核磁共振仪、分光光度计和傅里叶变换红外光谱仪等对 HA 纳米粒进行观测。结果 HA 纳米粒的平均尺寸为。10-30nm ;共振分析表明,磷至少以 2 种类型存在;在 200nm 波长处,光谱包含六面体 Ca2+ 典型的光谱带;HA 纳米粒微晶的 Eg 值分别为 1.60 和 1.64ev;傅里叶变换红外光谱中包含 2 种振波;在 956.5、1026.1 和 1108.7cm 光带处的 3 种 PO43- 曲态分别为ν1( PO4)、ν3(PO4)、ν3(PO4)。在 565.2 and 600.0cm 光带处的 2 种 PO43- 曲态为ν4(PO4)。结论纳米尺寸产生的从纳米粒到微晶的边缘能量增加伴随着簇晶体积的下降和 Ca2+ 周围配基的变化。这些变化与量子尺寸效应有关。
OBJECTIVE To prepare medical HA nanoparticles and observe their nanostructure and nano-size effects. Methods HA nanoparticles were prepared by normal surfactant (oil-in-water) and characterized by electron microscopy, X-ray diffraction, Spectrophotometer and Fourier transform infrared spectroscopy HA nanoparticles were observed. Results The average size of HA nanoparticles was Resonance analysis showed that there are at least two kinds of phosphorus in the sample. At 200nm, the spectrum contains the typical hexagonal Ca2 + band. The Eg values of HA nanoparticles are 1.60 and 1.64eV, respectively. Fourier transform infrared There are two kinds of vibration waves in the spectrum; the three kinds of PO43-flexural states at the bands of 956.5, 1026.1 and 1108.7 cm are ν1 (PO4), ν3 (PO4) and ν3 (PO4) respectively. The two PO43-flexures at 565.2 and 600.0 cm bands are ν4 (PO4). Conclusion The increase of edge energy from nanoparticle to microcrystal produced by nanometer size is accompanied by the decrease of cluster volume and the change of ligand around Ca2 +. These changes are related to quantum size effects.