与死疫苗或减毒活疫苗相比,仅含B 细胞及T 细胞决定簇的亚单位疫苗具有一定的优越性。但问题是大多数蛋白质虽可诱导抗体及CD_4~+MHCⅡ类限制性Th 及CTL,却不能诱导CD_8~+MHCⅠ类限制性CTL。本文作者发现,以免疫刺激复合物(ISCOMs)为佐剂,用HIV gp160或流感病毒血凝素皮下免疫小鼠一次,便可产生HIV 或流感病毒特异性CD_8~+MHCⅠ类限制性CTL,并且至少持续4个月,重复10次以上,效果稳定。反之,若以福氏佐剂与 Subunit vaccines containing only B-cell and T-cell determinants have some advantages over dead or attenuated live vaccines. But the problem is that most proteins can induce antibodies and CD_4 ~ + MHC class Ⅱ restricted Th and CTL, but can not induce CD_8 ~ + MHC class Ⅰ restricted CTL. The authors found that subcutaneously immunized mice with HIV gp160 or influenza virus hemagglutinin with the adjuvant immunostimulating complexes (ISCOMs) as adjuvant can produce HIV or influenza virus-specific CD8 + MHC class I restricted CTLs, and For at least 4 months, repeat more than 10 times, the effect is stable. Conversely, if with Freund’s adjuvant