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过敏是常见的临床表现,虽不危及患者生命,但因伴有瘙痒,故而使其日常生活、工作受到影响,导致生活质量下降。过敏的发病机制可能与机体产生针对IgE高亲和力受体(FcεRⅠ)或IgE的自身抗体、免疫分子、补体等诸多因素有关。近年来,对于抗FcεRⅠ和IgE自身抗体陆续有报道,根据其生物学活性及其与疾病的相关临床表现推测,这类抗体可能参与了具有过敏反应表现的自身免疫性疾病的发生和发展。但关于FcεRⅠ的一个新形式——血清可溶性IgE高亲和力受体(sFcεRⅠ),其与过敏疾病间的关系尚不明确。本文就目前研究较少的sFcεRⅠ进行简单介绍。
Allergy is a common clinical manifestation. Although it does not endanger the life of a patient, it causes its daily life and work to be affected due to the itching, which leads to a decrease in the quality of life. The pathogenesis of allergy may be related to the body produce antibodies against IgE high affinity receptor (FcεRI) or IgE autoantibodies, immune molecules, complement and many other factors. In recent years, autoantibodies to anti-FcεRI and IgE have been reported one after another. According to their biological activity and their clinical manifestations associated with the disease, these antibodies may be involved in the occurrence and development of autoimmune diseases with anaphylaxis. However, a new form of FcεRI - serum soluble IgE high affinity receptor (sFcεRI), its relationship with allergic diseases is not yet clear. In this paper, the current study of sFcεR Ⅰ less a brief introduction.