论文部分内容阅读
目的：观察丙氨瑞林对子宫内膜癌的治疗作用。方法：对诊刮确诊的１７例子宫内膜癌病人，予丙氨瑞林７００μｇ，ｉｍ，ｑｄ×７ｄ，用药前后作性激素测定及组织学检查。结果：绝经妇女用药后血中ＦＳＨ和ＬＨ下降（Ｐ＜０．０１和＜０．０５），雌二醇、孕酮及睾丸酮变化不明显。其中１３例内膜样腺癌用药后有丝分裂指数明显下降（Ｐ＜０．０１），有丝分裂指数变化与癌周内膜之反应有关。呈增生反应癌周内膜癌组织有丝分裂指数下降值明显高于呈萎缩状态癌周内膜。结论：丙氨瑞林治疗子宫内膜癌后能降低ＦＳＨ和ＬＨ水平，对子宫内膜癌尤其是雌激素依赖性内膜癌有一定疗效。
Objective: To observe the therapeutic effect of ararelin on endometrial carcinoma. Methods: Seventeen cases of endometrial cancer diagnosed by doctoring were treated with 700 μg of imrelin for im, qd × 7 days. Hormone and histological examination were performed before and after treatment. Results: The blood FSH and LH in postmenopausal women decreased (P <0.01 and <0.05), and the changes of estradiol, progesterone and testosterone were not obvious. Mitotic index decreased significantly in 13 cases of endometrial adenocarcinoma (P <0.01), and the change of mitotic index was related to the reaction of endometrial carcinoma. In proliferative reaction, the decrease of mitotic index in endometrial carcinoma was significantly higher than that in endometrial carcinoma, which showed atrophic state. Conclusion: Arelin may reduce FSH and LH levels after treatment of endometrial cancer, and have a certain effect on endometrial cancer, especially estrogen-dependent endometrial cancer.