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Hyaluronan (HA),a high molecular weight glycosaminoglycan in the extracellular matrix,hasbeen implicated in the promotion of malignant phenotypes,including tumor angiogenesis.However,little isknown about the effect of HA on tumor-associated lymphangiogenesis.In this study,mouse hepatocellularcarcinoma Hca-F cells combined with or without HA were injected subcutaneously into C3H/Hej mice,thenangiogenesis and lymphangiogenesis of implanted tumors were examined by immunostaining for platelet-endothelial cell adhesion molecule-1 and lymphatic vascular endothelial hyaluronan receptor-1 respectively.Interestingly,we found HA promotes tumor lymphangiogenesis and the occurrence of intratumoral lymphaticvessels,but has little effect on tumor angiogenesis.Moreover,HA also promotes intralymphatic tumorgrowth,although it is not sufficient to potentiate lymphatic metastasis.These results suggest that HA,which is elevated in most malignant tumor stroma,may also play a role in tumor progression by promotinglymphangiogenesis.
Hyaluronan (HA), a high molecular weight glycosaminoglycan in the extracellular matrix, hasbeen implicated in the promotion of malignant phenotypes, including tumor angiogenesis. However, little is known about the effect of HA on tumor-associated lymphangiogenesis. In this study, mouse hepatocellular carcinomacino Hca -F cells combined with or without HA were injected subcutaneously into C3H / Hej mice, thenangiogenesis and lymphangiogenesis of implanted tumors were examined by immunostaining for platelet-endothelial cell adhesion molecule-1 and lymphatic vascular endothelial hyaluronan receptor-1 respectively.Interestingly, we found HA promotes tumor lymphangiogenesis and the occurrence of intratumoral lymphaticvessels, but has little effect on tumor angiogenesis. Moreover, HA also promotes intralymphatic tumorgrowth, although it is not sufficient to potentiate lymphatic metastasis. These results suggest that HA, which is elevated in most malignant tumors stroma, may also play a role in tumor progression by pr omotinglymphangiogenesis.