酮康唑最初被认为是较安全的药物.当大规模使用时,它可如同其它在肝脏代谢的药物一样,引起肝损害,即化学性肝炎,有时甚至导致死亡,这种非常罕见的情况与长期应用酮康唑有关,但目前认为,只要合理用药,此药仍是安全的. Ketoconazole was originally considered to be a safer drug which, when used on a large scale, can cause liver damage, the same as other drugs metabolized in the liver, causing chemical hepatitis and sometimes death, a very rare condition Long-term use of ketoconazole, but now that, as long as the rational use of drugs, the drug is still safe.