随着分子生物学的发展,人们对混合配体配合物越来越重视。经典的Bjerrum形成函数方法,求得的是表观稳定常数,仅考虑了简单配合物,不能反映溶液真实配位平衡,对三元等复杂体系更无能为力。近年用大型计算机程序,可处理多元体系,测定精度提高。稀土在生理和药理方面的应用,也要考虑生物体中的排泄问题。稀土与蛋白质 With the development of molecular biology, more and more attention is paid to mixed ligand complexes. Classical Bjerrum formation function method, obtained is the apparent stability constant, taking into account only the simple complex, can not reflect the true equilibrium solution, ternary and other complex systems more powerless. In recent years, large-scale computer programs can handle multiple systems and improve the measurement accuracy. Rare earth in the physiological and pharmacological applications, but also to consider the issue of excretion in organisms. Rare earths and proteins