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目的 探讨洛赛克 (奥美拉唑 )口服治疗小儿消化性溃疡的合适剂量。方法 将 2 0例消化性溃疡患儿分成 2组 ,分别晨间 1次口服洛赛克 (0 .30～ 0 .6 0 )mg·kg-1·d-1(平均 0 .40± 0 10 )和 (0 .6 1～ 0 .90 )mg·kg-1·d-1(平均 0 .80± 0 10 ) ,监测治疗前、给药第 1天、第 1周及 4～ 6周 (平均 5周 )时胃 pH动态变化。 结果 治疗前和给药后不同时间各项胃 pH监测指标在两组之间的差异无显著性。两组患儿治疗后平均胃pH值、中位 pH值及胃 pH >3的时间百分比均大于治疗前 ,差异有显著性 ;而这 3项指标及药效维持时间在不同治疗时期的差异均无显著性。结论 洛赛克口服治疗小儿消化性溃疡的合适剂量为 0 .30～ 0 .6 0mg·kg-1·d-1(平均0 40mg·kg-1·d-1)。
Objective To investigate the appropriate dose of oral administration of omeprazole in children with peptic ulcer. Methods Twenty children with peptic ulcer were divided into two groups. One morning after oral administration of Losec (0.30-0.60) mg · kg-1 · d-1 (average 0.40 ± 0 10 ) And (0.6-1 ~ 0.90) mg · kg-1 · d-1 (average 0.80 ± 0 10). Before treatment, on the first day, the first week and the fourth to the sixth week Average 5 weeks) gastric pH dynamic changes. Results Before treatment and at different times after administration, there was no significant difference between the two groups in the monitoring of gastric pH. The mean gastric pH value, median pH value and gastric pH value> 3 after treatment in both groups were significantly higher than those before treatment, and the difference was significant between the three indexes and the maintenance time in different treatment periods No significant. Conclusion The appropriate dose of Oral Losec to treat peptic ulcer in children is 0.30 ~ 0.60 mg · kg-1 · d-1 (average 0 40 mg · kg-1 · d-1).