miRNA-711-SP1-collagen-I pathway is involved in the anti-fibrotic effect of pioglitazone in myocar

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：kentron

【摘要】

：

Although microRNAs(miRNAs) have been intensively studied in cardiac fibrosis,their roles in drug-mediated anti-fibrotic therapy are still unknown.Previously,Pio

【作者】

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ZHAO Na YU HaiYi YU HaiTao SUN

【机构】

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DepartmentofCardiology

【出处】

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中国科学：生命科学英文版

【发表日期】

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2013年5期

【关键词】

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心肌纤维化吡格列酮 Ⅰ型胶原心肌梗死心脏成纤维细胞血管紧张素Ⅱ MIRNA 小分子RNA pioglitazone miR-711 cardiac fi

【基金项目】

：

supported by the National Natural Science Foundation of China (81100164,31271212,81070196,81030001),the Research Fund for the Doctoral Program of Higher Education (20100001110101,20110001120015),the P

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Although microRNAs(miRNAs) have been intensively studied in cardiac fibrosis,their roles in drug-mediated anti-fibrotic therapy are still unknown.Previously,Pioglitazone attenuated cardiac fibrosis and increased miR-711 experimentally.We aimed to explore

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miRNA-711-SP1-collagen-I pathway is involved in the anti-fibrotic effect of pioglitazone in myocar

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