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目的:分析婴幼儿脓毒症患者早期炎性细胞因子及血培养检测的临床意义。方法:随机选取我院2012年2月至2014年5月住院治疗的婴幼儿脓毒症患者60例为观察组,并选取同期的健康婴幼儿61例为对照组,观察两组降钙素原(PCT)、软骨糖蛋白39(YKL-40)、超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)水平及血培养阳性率。结果:观察组治疗前PCT、YKL-40、hs-CRP、WBC水平及血培养阳性率与对照组差异均有统计学意义(P<0.05),且观察组治疗前后的PCT、YKL-40、hs-CRP、WBC水平及血培养阳性率均具有统计学差异(P<0.05);多项联合在各时期的敏感度均高于单项检测,且五项联合在各时期的敏感度均最高,12h后均为100%。结论:PCT、YKL-40、hs-CRP、WBC水平及血培养可用于婴幼儿脓毒症诊断,且五项联合的诊断敏感度最高。
Objective: To analyze the clinical significance of detection of early inflammatory cytokines and blood culture in infants with sepsis. Methods: Sixty infants and sepsis patients hospitalized in our hospital from February 2012 to May 2014 were randomly selected as the observation group. Sixty-one healthy infants in the same period were selected as the control group. Two groups of procalcitonin (PCT), YKL-40, hs-CRP, WBC and positive rate of blood culture. Results: Before treatment, the levels of PCT, YKL-40, hs-CRP, WBC and the positive rate of blood culture in the observation group were significantly different from those in the control group (P <0.05) hs-CRP, WBC and the positive rate of blood culture were statistically significant (P <0.05). The sensitivity of multiple combinations in each period were higher than that of single test, and the sensitivity of the five combinations were the highest in each period, After 12h are 100%. Conclusion: The levels of PCT, YKL-40, hs-CRP, WBC and blood culture can be used for the diagnosis of sepsis in infants and young children, and the diagnostic sensitivity of the five combinations is the highest.