目的　观察尼莫同超早期给药对小鼠局灶性脑梗死的影响。方法　经右侧颈总动脉将尼龙单丝线栓至大脑中动脉造成永久性缺血模型。经尾静脉及腹腔注射尼莫同 ,TTC染色、图像分析仪测定脑梗死体积。结果　单纯缺血组各时间点脑梗死体积最大 ,缺血前预防给药组各时间点脑梗死体积最小 ,缺血后即刻给药组各时间点脑梗死体积介于二者之间。结论　小鼠大脑中动脉闭塞后其局灶性脑梗死体积于术后第 3天达高峰。缺血前预防给药组、缺血后即刻给药 ,尼莫同均可使梗死体积减少 Objective To observe the effect of nimoton and ultra-early administration on focal cerebral infarction in mice. Methods A permanent ischemic model was established by tethering nylon monofilaments to the middle cerebral artery via the right common carotid artery. The tail vein and intraperitoneal injection of Nemo, TTC staining, image analysis of cerebral infarction volume. Results The infarct volume of ischemic group was the largest at each time point. The volume of cerebral infarction at each time point was the lowest in the ischemic preconditioning group. The volume of cerebral infarction at each time point immediately after ischemia was between the two groups. Conclusion The volume of focal cerebral infarction reached its peak on the third day after the occlusion of the middle cerebral artery in mice. Premedication prevention group, administered immediately after ischemia, nimodipine can reduce infarct size