Mechanosensation, the ability to detect mechanical forces, underlies the senses of hearing,balance, touch, and pain, as well as renal and cardiovascular regulat
Transient Receptor Potential (TRP) channels have emerged as cellular sensors of extra-and intracellular environment.Among them, the canonical TRP (TRPC) protein
Background: Transient receptor potential (TRP) channels, a group of ligand-gated, Ca2+ permeable ion channels, act as polymodal nociceptors in peripheral neuron
As a member of the TRPM subfamily, melastatin transient receptor potential 2 (TRPM2)channel is a Ca2+-permeable cationic channel activated by intracellular ADP-
My lab has been focused on creating novel technologies and reagents for studying calcium signaling, understanding molecular basis of diseases, and diagnostics a
Histamine H4 receptor has been recognized to play a role in evoking peripheral pruritus.However, the ionic and intracellular signaling mechanism of activation o