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目的探讨血清中缺血修饰清蛋白(IMA)水平在经皮冠状动脉介入术(PCI)前后变化规律,从而评价IMA在PCI治疗急性冠脉综合征(ACS)患者中的临床应用价值。方法收集本院心内科拟诊为ACS并择期接受经皮冠状动脉介入术的50例患者的标本,检测其经皮冠状动脉介入术前、术后即刻、术后30min、6h、12h血清中IMA的浓度的变化。结果 PCI术后即刻IMA水平继续较术前增高,且与PCI术中球囊扩张次数、扩张压力、扩张时间呈正相关,30min IMA水平开始下降,6h渐降至正常,12h恢复到基线水平。结论 IMA水平与心肌缺血程度呈正相关,并为临床上PCI手术治疗急性冠脉综合征患者手术效果的判定和手术成功率的评估提供客观的量化依据。
Objective To investigate the changes of serum IMA (IMA) levels before and after percutaneous coronary intervention (PCI) and evaluate the clinical value of IMA in the treatment of patients with acute coronary syndrome (ACS). Methods Fifty patients who were diagnosed as ACS and undergoing percutaneous coronary intervention were enrolled in this study. Serum samples were collected before and after percutaneous coronary intervention (PCI), immediately after operation, at 30min, 6h, 12h after operation The concentration of the changes. Results Immediately after PCI, the level of IMA continued to increase, which was positively correlated with the number of balloon dilatation, dilation pressure and dilation time. The level of IMA began to decline at 30 min, then decreased to normal level at 6 h, and returned to baseline at 12 h. Conclusions There is a positive correlation between the level of IMA and the degree of myocardial ischemia, and provide an objective and quantitative basis for judging the surgical effect and evaluating the success rate of surgery in patients undergoing PCI for acute coronary syndrome.