论文部分内容阅读
有报道使用α-氨基-3-羟基-5-甲基-4-异噁唑(AMPA)受体拮抗剂的延迟疗效较N-四基-D-天冬氨酸(NM-DA)受体拮抗剂更能完全抑制谷氨酸的神经毒性。本文研究了AMPA受体拮抗剂YM90K的神经保护作用。由血栓梗塞鼠的中脑动脉(MCA)诱发局灶脑损伤,梗塞后24～72小时采用组织化学技
It has been reported that the delayed effect of the use of the [alpha] -amino-3-hydroxy-5-methyl-4-isoxazole (AMPA) receptor antagonist is more pronounced than that of the N-tetrayl-D-aspartate Antagonists can more completely inhibit the neurotoxicity of glutamate. This article studies the neuroprotective effect of AMPA receptor antagonist YM90K. The focal brain injury was induced by the middle cerebral artery (MCA) in rats with thromboembolism. Tissue chemistry was performed 24 to 72 hours after infarction