A群链球菌是一种常见的人类致病菌,可以引起人类的化脓性感染和非化脓性后遗症。A群链球菌能表达或分泌多种毒力因子参与其致病性。大量文献报道,纤溶酶原也是A群链球菌侵入机体的重要因子,A群链球菌通过其纤溶酶原受体能与纤溶酶原特异性结合,从而使与A群链球菌结合的纤溶酶原更易被激活为纤溶酶。纤溶酶能降解宿主的细胞外基质和基底膜,有利于A群链球菌在人体内的扩散。本文就A群链球菌如何激活并利用人纤溶酶原的机制进行了综述。 Group A Streptococcus is a common human pathogen that causes human suppurative infections and non-suppurative sequelae. Group A Streptococcus can express or secrete a variety of virulence factors involved in its pathogenicity. A large number of papers reported that plasminogen is also a group A streptococcus invade the body of an important factor, Streptococcus group A through its plasminogen receptor with plasminogen specific binding, so that the group A streptococcal Plasminogen is more easily activated as plasmin. Plasmin can degrade the extracellular matrix of the host and the basement membrane, is conducive to the spread of Streptococcus group A in the human body. This article reviews the mechanism of how Group A Streptococci activate and utilize human plasminogen.