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目的:探讨耐药基因产物P-糖蛋白(P-glycoprotein,P-gp)的表达与维吾尔族(维族)、汉族宫颈癌新辅助化疗疗效的相关性。方法:62例宫颈癌患者(宫颈癌组)中汉族40例,维族22例,均接受新辅助化疗;50例宫颈组织正常者(对照组)中汉族30例,维族20例。应用免疫组织化学SP法检测2组P-gP的表达情况,并进行比较。结果:2组P-gp的表达在维、汉2个民族间差异无统计学意义(P>0.05);宫颈癌组P-gp表达水平明显高于对照组,差异有统计学意义(P<0.05)。新辅助化疗有效率P-gp表达阳性患者(72.5%)明显低于表达阴性患者(100.0%)(P<0.05),新辅助化疗疗效在维、汉2个民族间差异无统计学意义(P>0.05);P-gp表达与民族、新辅助化疗疗效、临床分期、分化程度及淋巴结转移均无相关性(P>0.05)。结论:P-gp的表达可能与宫颈癌发生、发展相关,P-gp的表达不仅在宫颈癌耐药机制中发挥重要作用,且与化疗疗效密切相关。
Objective: To investigate the relationship between the expression of P-glycoprotein (P-gp) and the efficacy of neoadjuvant chemotherapy in Uygur and Han nationality cervical cancer patients. Methods: Forty-two Han patients and 22 Uighurs in 62 cases of cervical cancer (cervical cancer group) underwent neoadjuvant chemotherapy. Thirty cases of Han and 50 cases of normal cervical tissue (control group) were included in this study. The expression of P-gp in two groups was detected by immunohistochemical SP method and compared. Results: There was no significant difference in P-gp expression between the two ethnic groups in Victoria and Han (P> 0.05). The expression of P-gp in cervical cancer group was significantly higher than that in control group (P < 0.05). The neoadjuvant chemotherapy-positive P-gp expression positive patients (72.5%) was significantly lower than that of the negative expression patients (100.0%) (P <0.05), Neoadjuvant chemotherapy efficacy in Victoria and Han two ethnic groups was no significant difference (P > 0.05). There was no correlation between the expression of P-gp and the national, neoadjuvant chemotherapy, clinical stage, differentiation and lymph node metastasis (P> 0.05). Conclusion: The expression of P-gp may be related to the occurrence and development of cervical cancer. The expression of P-gp not only plays an important role in the mechanism of cervical cancer resistance, but also is closely related to the curative effect of chemotherapy.