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位于石川县内的挂桥河流域受其上游某矿的镉污染。1974和1975年由该县组织的流行病学调查发现,50岁以上的2,691名居民中有206名(7.7%)维生素A结合蛋白(RBP)排出量高于4 mg/L。本研究以1974~1982年间对石川县挂桥河流域居民的追踪调查为基础,以探明镉污染对健康的影响。肾脏是镉的重要靶器官,低分子蛋白尿,如维生素A结合蛋白尿,β_2-微球蛋白尿,是表明镉引起肾损伤的早期指标。许多报告也证
The Han River Bridge in Ishikawa is contaminated by cadmium in a certain mine in its upper reaches. Epidemiological surveys conducted by the county in 1974 and 1975 found that 206 (7.7%) of 2,691 inhabitants over the age of 50 had a greater than 4 mg / L vitamin A-binding protein (RBP) excretion. This study was based on the follow-up survey of residents in Jiaqiao River Basin in Ishikawa Prefecture from 1974 to 1982 to find out the health effects of cadmium pollution. Kidney is an important target organ of cadmium, low molecular proteinuria, such as vitamin A-binding proteinuria, β 2 -microglobulin, is an early indicator of cadmium-induced renal injury. Many reports also prove