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目的探讨白细胞介素-2(IL-2)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)对癫痫患者的神经免疫调节作用。方法采用双抗体夹心酶联免疫吸附试验(ELISA)检测45例癫痫患者血清中IL-2、IL-6和TNF-α的水平,并与年龄和性别相匹配的40例正常对照组进行比较。结果癫痫组血清IL-2、IL-6和TNF-α的水平均明显高于对照组(P<0.01)。相关分析发现癫痫患者血清IL-2、IL-6与TNF-α水平之间呈显著正相关(r=0.49,P<0.01;r=0.56,P<0.01)。结论癫痫患者的免疫系统处于活化状态,细胞因子水平的失衡参与了癫痫的免疫病理过程。
Objective To investigate the neuroimmunological effects of interleukin-2 (IL-2), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF- α) on epileptic patients. Methods The levels of IL-2, IL-6 and TNF-α in sera of 45 patients with epilepsy were detected by ELISA. The age and sex matched 40 normal controls were compared. Results The levels of serum IL-2, IL-6 and TNF-α in epilepsy group were significantly higher than those in control group (P <0.01). Correlation analysis showed that there was a significant positive correlation between serum IL-2, IL-6 and TNF-α levels in patients with epilepsy (r = 0.49, P <0.01; r = 0.56, P <0.01). Conclusion The immune system of patients with epilepsy is in an activated state. The imbalance of cytokine levels is involved in the immunopathological process of epilepsy.