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心室颤动是危急症。目前临床上抢救室颤病人较有效的方法是电去颤,有很大的条件限制。Lawson用氯仿引起小白鼠室颤,作预防室颤的药物筛选实验时,曾用极大剂量的阿托品(102mg/kg)。Cagin和Natelson发现大剂量阿托品(5mg/kg)可预防因哇巴因灌流豚鼠引起的室速、室颤或心搏抑制。我们曾用阿托品作预防毒毛旋花子甙—K引起的兔心律失常的观察,发现阿托品有显著的效果,并提出其机制可能是因阿托品阻断迷走亢进后,恢复窦性心律和房室传导,使之胜过并抑制心室异搏节律,即产生驱动性超速抑制(overdrive suppression)的结果。阿托品的这种作用是否对治疗某些室颤有效?它与某些抗心律失常药物制合用能否增加疗效?是本实验企图解决的问题。
Ventricular fibrillation is a critical condition. At present, the most effective way to rescue VF in clinic is to defibrillator, which has a lot of limitations. Lawson uses chloroform to induce ventricular fibrillation in mice. For drug screening tests to prevent VF, a very high dose of atropine (102 mg / kg) was used. Cagin and Natelson found that high doses of atropine (5 mg / kg) prevented ventricular fibrillation or ventricular fibrillation induced by ouabain perfusion in guinea pigs. We have used atropine for the prevention of venom arrhizus-K induced arrhythmia in rabbits and found that atropine has a significant effect and proposed that the mechanism may be due to atropine block after the hyperkinetic, restore sinus rhythm and atrioventricular conduction , To outperform and inhibit the ventricular beatings rhythm, the result of driving overdrive suppression. Is this effect of atropine effective for the treatment of certain ventricular fibrillation? Is it possible to increase efficacy with certain anti-arrhythmic drugs? It is an attempt to solve the problem in this experiment.