目的探讨CO_2激光切除侵犯前联合的早期声门癌的临床安全性及疗效。方法回顾性分析26例行CO_2激光治疗的侵犯前联合的早期声门型喉癌患者临床资料,肿瘤标本术中冰冻、术后HE染色行镜下切缘观察,术后严格随访观察局部复发情况。结果切缘阴性20例,阳性6例,随访3年中局部复发7例,复发率为26.9%(7/26),其中切缘阳性复发率为83.3%(5/6),切缘阴性复发率为10%(2/20),组间差异有统计学意义(P=0.002)。结论 CO_2激光治疗累及前联合的早期声门型喉癌喉功能保全良好,疗效可靠,但需严格把握手术适应证以确保切缘安全,降低局部复发率。 Objective To investigate the clinical safety and efficacy of CO_2 laser ablation of the early combined glottic carcinoma. Methods The clinical data of 26 patients with early glottic laryngeal carcinoma treated with CO_2 laser retrospectively were retrospectively analyzed. The tumor specimens were frozen intraoperatively and were stained by hematoxylin and eosin (HE) staining. The local recurrence was observed after strict follow-up. Results There were 20 cases with negative margins and 6 cases with positive margins. The recurrence rate was 26.9% (7/26) in 7 cases followed up for 3 years. The positive rate of recurrence was 83.3% (5/6) The rate was 10% (2/20), with significant difference between groups (P = 0.002). Conclusions The laryngeal function of early glottic laryngeal cancer treated with CO_2 laser treatment is well preserved and reliable. However, surgical indications should be strictly followed to ensure margin safety and reduce the local recurrence rate.