目的探讨系统性红斑狼疮(SLE)患者外周血B淋巴细胞亚群的变化及其与病情活动的相关性。方法用流式细胞仪检测了27例SLE患者及16名正常对照人群的外周血B淋巴细胞亚群。SLE活动性的判断采用SLEDAI评分方法,其中缓解期的患者11例,活动期的患者16例。分析以上SLE患者外周血B淋巴细胞亚群变化及其与病情活动的相关性。结果SLE患者外周血B1淋巴细胞亚群的百分比、B1淋巴细胞亚群/B2淋巴细胞亚群的比值显著高于正常对照,但未见其与病情活动相关。结论SLE患者外周血B1淋巴细胞亚群存在异常,可能在SLE的发病中具有重要作用。 Objective To investigate the changes of peripheral blood B lymphocyte subsets in patients with systemic lupus erythematosus (SLE) and its relationship with disease activity. Methods Flow cytometry was used to detect peripheral blood B lymphocyte subsets in 27 SLE patients and 16 normal control subjects. SLE activity to determine the use of SLEDAI score method, including 11 patients with remission, active in 16 patients. Analysis of the above SLE patients with peripheral blood B lymphocyte subsets and its relationship with the disease activity. Results The percentage of B1 lymphocyte subsets and the ratio of B1 lymphocyte subsets / B2 lymphocyte subsets in peripheral blood of SLE patients were significantly higher than those of normal controls, but no correlation was found between them. Conclusion Abnormalities of B1 lymphocyte subsets in peripheral blood of SLE patients may play an important role in the pathogenesis of SLE.