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目的探讨原发性肝癌(HCC)患者TACE前后血清血管内皮生长因子(VEGF)水平和CT灌注参数之间的关系。资料与方法对17例HCC患者于TACE术前1天及术后7~10天测量血清VEGF水平,同时行CT灌注扫描,计算肝血流量(HBF)、肝动脉灌注分数(HAF),肝动脉灌注量(HAP)、门静脉灌注量(PVP)。结果原发性肝癌TACE前后HBF、HAP差异有统计学意义,血清VEGF与HBF、HAF、HAP呈正相关。结论血清VEGF水平及CT灌注可帮助评价肝癌TACE疗效。
Objective To investigate the relationship between the level of serum vascular endothelial growth factor (VEGF) and CT perfusion parameters in patients with primary hepatocellular carcinoma (HCC) before and after TACE. Materials and Methods Serum VEGF levels were measured in 17 patients with HCC at 1 day before TACE and 7-10 days after operation. CT perfusion scan was performed simultaneously to calculate the hepatic blood flow (HBF), hepatic artery perfusion score (HAF), hepatic artery Perfusion volume (HAP), portal vein perfusion (PVP). Results There were significant differences in HBF and HAP before and after TACE in primary hepatocellular carcinoma. Serum VEGF was positively correlated with HBF, HAF and HAP. Conclusion Serum VEGF levels and CT perfusion can help evaluate the efficacy of TACE for hepatocellular carcinoma.