2型糖尿病患者存在高真胰岛素血症及高胰岛素原血症,二者与糖尿病血管病变的发生有密切关系。其可能机制为影响脂代谢,促进肝及血管内皮细胞血浆纤溶酶原激活物抑制剂-1合成,引起血管内皮细胞凋亡,影响血管活性物质合成,释放,兴奋交感神经系统等。 Type 2 diabetes patients with hyperinsulinemia and hyperinsulinism, both with the occurrence of diabetic vascular disease are closely related. Its possible mechanism is to affect lipid metabolism, promote plasma and plasminogen activator inhibitor-1 synthesis in liver and vascular endothelial cells, cause apoptosis of vascular endothelial cells, affect the synthesis and release of vasoactive substances, and excite the sympathetic nervous system.