动脉导管于出生后肺呼吸开始的同时旋即功能性闭锁,其闭锁与动脉血氧分压及前列腺素有关。未成熟儿特别是发生呼吸窘迫综合征时,常并发动脉导管来闭(PDA)。自1976年报告前列腺合成阻滞剂——消炎痛有可能治疗未成熟儿的 PDA 以来,该疗法已在全世界普及。但是,对前列腺素合成阻滞剂无反应,只好行手术结扎的为多见。在胎内有慢性低氧血症的宫内生长 Arterial catheters immediately after the birth of lung respiration at the beginning of functional atresia, the block and arterial oxygen partial pressure and prostaglandin related. Immature children, especially in the case of respiratory distress syndrome, often accompanied by patent ductus arteriosus (PDA). Since 1976, it has been reported that it is possible to treat PDA in immature children with indomethacin, an anti-inflammatory drug, which has become widespread throughout the world. However, no response to prostaglandin synthesis blockers, but the surgical ligation is more common. Intrauterine growth in the fetus with chronic hypoxemia