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目的探讨慢性阻塞性肺疾病并发肺结核(COPD-PTB)的危险因素。方法采用以医院为基础的频数匹配病例对照研究方法,收集经确诊的105例COPD-PTB病例和105例对照的各项资料,采用单因素和多因素非条件logistic回归法筛选危险因素。结果单因素logistic回归分析显示,体重、文化程度、婚姻状况、职业、应激事件等15个变量影响COPD-PTB发病;多因素logistic回归分析显示,体重(OR=0.637)、文化程度(OR=0.654)、应激事件(OR=3.554)、结核病接触史(OR=3.187)、吸烟(OR=3.547)、接触粉尘史(OR=2.560)、取暖方式采用柴草土暖(OR=2.649)或者煤炉(OR=2.418)为COPD-PTB发病的重要影响因素。结论体重较轻、文化程度低、有应激事件、结核病接触史、吸烟、接触粉尘、柴草土暖或煤炉取暖等,是COPD-PTB发病的危险因素。
Objective To explore the risk factors of pulmonary tuberculosis (COPD-PTB) in patients with chronic obstructive pulmonary disease. Methods A hospital-based frequency matching case-control study was used to collect the data of 105 confirmed cases of COPD-PTB and 105 controls. The risk factors were screened by univariate and multivariate non-conditional logistic regression. Results One-way logistic regression analysis showed that 15 variables such as body weight, education, marital status, occupational stress and stress events affected COPD-PTB. Multivariate logistic regression analysis showed that body weight (OR = 0.637) (OR = 3.554), history of exposure to tuberculosis (OR = 3.187), smoking (OR = 3.547) and history of exposure to dust (OR = 2.560) Furnace (OR = 2.418) is an important factor in the pathogenesis of COPD-PTB. CONCLUSION: COPD-PTB is a risk factor for COPD-PTB with light weight, low education level, stressful events, history of exposure to TB, smoking, exposure to dust, warm earth by firewood, or heating of coal stoves.