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[目的]探讨影响I型糖尿病患者糖尿病肾病(DN )发病的影响因素.[方法]在本院接受治疗的142例Ⅰ型糖尿病患者.按照是否患有DN分为DN组和非DN组.收集患者入院时的临床资料,主要包括:性别、年龄、糖尿病程、血尿酸等.以是否发生DN为自变量,其他相关指标为因变量进行logistics单因素及多因素回归分析,探讨影响I型糖尿病患者DN发病的相关因素.[结果]DN组患者糖尿病病程、糖化血红蛋白(HbA1C) 、舒张压、血尿酸、血红蛋白(Hb)水平分别为(8 .31 ± 2 .28)年、(10 .21 ± 3 .41)%、(81 .59 ± 12 .72) mm Hg 、(306 .38 ± 129 .02)μmol／L 、(116 .82 ± 20 .31)g／L ,明显高于对照组的(4 .06 ± 1 .96)年、(9 .41 ± 2 .51)%、(75 .24 ± 9 .61)mm Hg 、(258 .49 ± 92 .17 )μmol／L 、(131 .41 ± 14 .41 )g／L ,且两组比较差异均有显著性( P ＜0 .05) .单因素logistics回归分析结果显示,糖尿病程≥5年、HbA1C 、血尿酸、舒张压、Hb均与DN发病具有相关性( P ＜0 .05) .多因素logistics回归分析显示,糖尿病程≥5年、HbA1C 、舒张压、血尿酸、Hb是DN发病的独立危险因素( P ＜0 .05) .[结论]糖尿病程≥5年、HbA1C 、舒张压、血尿酸、Hb是DN发病的独立危险因素,I型糖尿病患者应积极控制血压、血糖,纠正尿酸水平.“,”To explore the factors that influenced the onset of diabetic nephropathy (DN ) in pa‐tients with type 1 diabetes .[M ethods]A total of 142 patients admitted to our hospital with type 1 diabetes were selected .According to w hether there is DN ,patients were divided into DN group and non‐DN group .T he clinical data of patients were collected ,including gender ,age ,duration of diabetes ,blood uric acid .Taking DN as an independent variable and other related indicators as the dependent variable ,logistic single factor and mul‐tivariate regression analysis were used to explore the factors influencing the pathogenesis of DN in patients with type 1 diabetes[Results]In the DN group ,the duration of diabetes ,HbA1C ,diastolic blood pressure , blood uric acid and Hb were (8 .31 ± 2 .28)years ,(10 .21 ± 3 .41)%,(81 .59 ± 12 .72)mm Hg 、(306 .38 ± 129 .02 ) μmol／L and(116 .82 ± 20 .31 )g／L , respectively ,w hich were significantly higher than those in the non‐DN group ,i.e.(4 .06 ± 1 .96)years ,(9 .41 ± 2 .51)%,(75 .24 ± 9 .61)mm Hg ,(258 .49 ± 92 .17)μmol／L and(131 .41 ± 14.41)g／L ,respectively .T he differences between the two groups were statistically significant ( P ＜0 .05).Un‐ivariate logistic regression analysis showed that the duration of diabetes ≥ 5 years ,HbA1C ,serum uric acid , diastolic blood pressure ,Hb were associated with the onset of DN ( P ＜0 .05).M ultivariate logistic regression analysis showed that the duration of diabetes ≥5 years ,HbA1C ,diastolic blood pressure ,blood uric acid and Hb were independent risk factors for DN ( P ＜0 .05).[Conclusion]Diabetes duration ≥ 5 years ,HbA1C ,di‐astolic blood pressure ,blood uric acid and Hb are independent risk factors for the onset of DN ,therefore pa‐tients with type 1 diabetes should actively control blood pressure ,blood sugar ,and uric acid levels .