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目的:观察毛冬青对腹主动脉缩窄致高血压大鼠一氧化氮(NO)、内皮素-1(ET-1)的影响。方法:大鼠50只采用腹主动脉缩窄法致高血压大鼠模型,设立空白组、模型组、卡托普利组(卡托组)、毛冬青高剂量组(毛高组)及毛冬青低剂量组(毛低组),各组动物于造模4周后开始给相应药物灌胃,治疗2周后采用无创血压仪测量鼠尾动脉血压,并测定大鼠血中ET-1、NO的含量。结果:术后4周,模型组、卡托组、毛高组、毛低组收缩压较空白组升高明显(P<0.01),分别给药干预6周后,卡托组、毛高组、毛低组收缩压较模型组下降(P<0.01)。造模后,模型组NO含量较空白组明显降低(P<0.01),ET-1含量较空白组明显增高(P<0.01);与模型组比较,毛冬青高剂量及卡托普利治疗能不同程度升高血清NO含量(P<0.01,P<0.05);毛冬青高剂量、卡托普利及毛冬青低剂量治疗能不同程度降低ET-1含量(P<0.01,P<0.05)。结论:毛冬青能改善腹主动脉缩窄大鼠血管内皮功能,并且呈一定的量效关系。
Objective: To observe the effects of Mao dongqing on nitric oxide (NO) and endothelin-1 (ET-1) in hypertensive rats with abdominal aorta stenosis. Methods: Fifty rats were randomly divided into three groups: model group, captopril group (Cato group), Mao Dongqing high dose group (Mao group) and hair Low-dose group (hair low group), the animals in each group began to give the corresponding drugs 4 weeks after the model was established. After 2 weeks of treatment, the rat caudal arterial blood pressure was measured by noninvasive blood pressure meter. The levels of ET- NO content. Results: At 4 weeks after operation, the systolic blood pressure of model group, Cato group, hair high group and hair low group were significantly higher than that of blank group (P <0.01). After intervention for 6 weeks, , And the systolic blood pressure in hair low group decreased compared with model group (P <0.01). After modeling, the content of NO in model group was significantly lower than that in blank group (P <0.01), and the content of ET-1 in model group was significantly higher than that in blank group (P <0.01). Compared with model group, high dose of Mao Dongqing and captopril treatment (P <0.01, P <0.05). The high dose of Mao Dongqing, captopril and Mao Dongqing treatment could decrease ET-1 content (P <0.01, P <0.05) to some extent. Conclusion: Mao dongqing can ameliorate vascular endothelial function in abdominal aorta constriction rats and show a certain dose-effect relationship.