论文部分内容阅读
目的探讨早期急性心肌梗死(AMI)患者血清缺血修饰白蛋白(IMA)及脂联素(APN)的相关性及临床价值。方法选择胸痛发作在6 h内的疑似AMI患者180例,其中108例确诊为AMI(AMI组),余72例为非AMI(NAMI组),同期选择50例健康体检者为正常对照组,检测血清IMA(游离钴比色法)及APN(ELISA法)水平,进行统计学处理与分析。结果 AMI组血清IMA水平显著高于对照组(t=24.541,P<0.01)及NAMI组(t=10.711,P<0.01),血清APN水平显著低于对照组(t=7.453,P<0.01)及NAMI组(t=7.109,P<0.01)。NAMI组血清IMA水平显著高于对照组(t=15.079,P<0.01),血清APN水平与对照组比较差异未见统计学意义(t=1.016,P>0.05)。早期AMI患者血清IMA水平与血清APN水平呈负相关(r=-0.549,P<0.01)。结论早期AMI患者血清IMA与血清APN呈负相关,联合检测疑似早期AMI患者血清IMA与APN水平有助于AMI的早期临床诊断,也有利于临床疗效观察。
Objective To investigate the correlation and clinical value of serum ischemic modified albumin (IMA) and adiponectin (APN) in patients with early acute myocardial infarction (AMI). Methods One hundred and eighty suspected AMI patients with chest pain onset within 6 h were selected, of which 108 were diagnosed as AMI (AMI group) and the other 72 were non-AMI (NAMI group). Fifty healthy subjects were selected as normal control group during the same period. Serum IMA (free cobalt colorimetric method) and APN (ELISA method) levels, for statistical analysis and analysis. Results The level of serum IMA in AMI group was significantly higher than that in control group (t = 24.541, P <0.01) and NAMI group (t = 10.711, P <0.01) And NAMI group (t = 7.109, P <0.01). The level of serum IMA in NAMI group was significantly higher than that in control group (t = 15.079, P <0.01). There was no significant difference in serum APN levels between the two groups (t = 1.016, P> 0.05). Serum IMA levels in early AMI patients were negatively correlated with serum APN levels (r = -0.549, P <0.01). Conclusions Serum IMA of early AMI patients is negatively correlated with serum APN. Combined detection of serum IMA and APN levels in patients with suspected early AMI is helpful for the early clinical diagnosis of AMI, and is also beneficial to the clinical observation.