论文部分内容阅读
目的探讨MRI评价再发缓解型多发性硬化患者脑干横截面积及其临床意义。方法临床选择2015年6月~2017年3月本院收治的再发缓解型多发性硬化患者15例为疾病组,另选取同期健康体检者15例为对照组,应用MRI检查两组的中脑面积、桥脑面积和延髓面积,评估疾病组与对照组的中脑面积、桥脑面积和延髓面积;采用美国国立卫生研究院卒中量表评估患者神经功能情况,评估疾病组脑组织不同萎缩程度的神经功能情况。结果疾病组的中脑面积、桥脑面积、延髓面积分别为(56.6±7.3)、(34.8±4.8)、(15.8±3.7)mm~2显著低于对照组的(78.5±8.9)、(50.4±10.9)、(36.9±4.8)mm~2,差异有统计学意义(P<0.05);疾病组的再发缓解型多发性硬化脑萎缩分级1~2级者的NIHSS评分(16.6±3.3)分显著低于3~4级的(28.5±8.9)分,差异有统计学意义(P<0.05)。结论 MRI可用于评估再发缓解型多发性硬化患者的脑萎缩程度,进而提高对再发缓解型多发性硬化患者病情危险程度评估的准确性及实施针对性治疗措施的预见性。
Objective To investigate the clinical value of MRI in evaluating the brainstem cross-sectional area of patients with relapsing-remitting multiple sclerosis. Methods Clinical selection From June 2015 to March 2017, 15 patients with remission-remitting multiple sclerosis in our hospital were selected as the disease group. Another 15 healthy subjects were selected as the control group. MRI was used to examine the midbrain Area, pontine area and medulla oblongata area. The midbrain area, pontine area and medulla oblongata area of the disease group and the control group were evaluated. The neurological function of the patients was evaluated by using the National Institutes of Health Stroke Scale, and the differences of brain tissue atrophy The neurological status. Results The area of midbrain, pontine area and medulla oblongata were (56.6 ± 7.3), (34.8 ± 4.8) and (15.8 ± 3.7) mm ~ 2 in the disease group were significantly lower than those in the control group (78.5 ± 8.9 and 50.4 (36.9 ± 4.8) mm ~ 2, the difference was statistically significant (P <0.05). The NIHSS score of the patients with recurrent remission-type multiple sclerosis with atrophy grade 1 ~ 2 was 16.6 ± 3.3, (28.5 ± 8.9) points lower than Grade 3 ~ 4, the difference was statistically significant (P <0.05). Conclusion MRI can be used to evaluate the extent of brain atrophy in patients with relapsing-remitting multiple sclerosis and to improve the accuracy of the assessment of the severity of the disease and the predictability of targeted therapies in patients with relapsing-remitting multiple sclerosis.