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选用大白鼠５８只随机分组，对照组鼠肺内局部注入生理盐水，实验组注入大、小剂量不同的顺铂。结果表明：对照组与实验组注射局部均出现不同程度的组织反应（局部充血、水肿、炎性细胞浸润、出血等），以大剂量组反应最重，而且该组大白鼠食量减少，体重下降，全身反应亦最重，小剂量组及对照组则全身反应校轻、体重及食量均增加．大部分大白鼠损伤在注药后４周内恢复，少数大剂量组的大白鼠４周后仍可见间质性肺炎。提示：肺癌患者若局部用顺铂应注意选择药物浓度及间隔时间。
Fifty-eight rats were randomly divided into control group and control group. Rats in the lungs were injected with normal saline. The experimental group was infused with large and small doses of cisplatin. The results showed that there were different degrees of tissue reaction (congestion, edema, infiltration of inflammatory cells, hemorrhage, etc.) in the control group and the experimental group, the heaviest reaction was in the high-dose group, and the food intake and body weight of the rats decreased , Systemic reaction is the heaviest, low-dose group and control group, systemic reaction school weight, body weight and appetite increased. Most of the damage in rats recovered within 4 weeks after injection, a small number of large doses of rats 4 weeks after the interstitial pneumonia is still visible. Tip: If patients with lung cancer with cisplatin should pay attention to select the drug concentration and interval time.