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目的:探讨检测尿微量白蛋白(UmALB)及尿视黄醇结合蛋白(RBP)对尿常规正常的肝硬化患者肾损害诊断的价值。方法:采用放免法测定35例肝硬化患者及30例体检正常者的尿微量白蛋白及视黄醇结合蛋白。结果:肝硬化组各种尿微量白蛋白及视黄醇结合蛋白均高于对照组,且随肝功能Child分级逐步升高,数值逐步升高。ChildB、C组的UmALB及RBP与Child A组及正常组相比差异显著(P<0.05)。结论:尿微量白蛋白及视黄醇结合蛋白测定有助于早期发现肝硬化患者肾小球和肾小管损害的存在,并且能反映随肝功能下降而加重的损害程度。
Objective: To investigate the value of urine microalbuminuria (UmALB) and urinary retinol binding protein (RBP) in the diagnosis of renal damage in patients with normal urinary cirrhosis. Methods: Urinary microalbumin and retinol binding protein in 35 patients with cirrhosis and 30 normal controls were determined by radioimmunoassay. Results: The urinary microalbumin and retinol binding protein in cirrhosis group were higher than those in control group, and gradually increased with the grading of liver function. The values gradually increased. There was significant difference between ChildB and C group (P <0.05). Conclusion: The determination of urinary microalbumin and retinol binding protein can help early detection of glomerular and tubular damage in patients with cirrhosis, and can reflect the degree of damage that aggravates with decreasing liver function.