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本文报告用手术摘除的Graves病(甲亢)患者甲状腺组织自制成的细胞膜受体制剂和可溶性TSH(促甲状腺激素)受体制剂为结合剂,以ELISA法对几种常见的甲状腺病患者血清中的甲状腺刺激性抗体(Thyroid Stimulating Antibody,TsAb),进行了检测及方法学探讨.结果显示,64例Graves病和54例正常人测得的血清TsAb OD值((?)±s)分别为1.14±0.20和0.48±0.08,差异有极显著意义(P<0.001),Graves病的检出阳性率达95.3％.本法具有灵敏度高、操作简便、重复性好的优点,可为Graves病的诊断、治疗与研究提供有用的指标。
This article reports the self-made plasma membrane receptor preparations and soluble TSH (thyroid stimulating hormone) receptor preparations from thyroid tissue of patients with Graves disease (hyperthyroidism) Of thyroid stimulating antibody (Thyroid Stimulating Antibody, TsAb) were detected and methodological study results showed that 64 cases of Graves disease and 54 normal people measured serum TsAb OD value (± s) were 1.14 ± 0.20 and 0.48 ± 0.08 respectively, the difference was significant (P <0.001), and the positive rate of Graves ’disease was 95.3% .This method has the advantages of high sensitivity, simple operation and good repeatability, which can be used to diagnose Graves’ disease , Treatment and research provide useful indicators.