论文部分内容阅读
C1q除了在激活补体的传统途径中发挥作用外,亦通过补体C3受体或自身受体在促进吞噬、与抗靶细胞抗体的相互作用上发挥重要作用。与人类C1q结合的细胞表面受体有两种:C1q-R,为60kDa的糖蛋白,与C1q的胶原样区域结合;gC1q-R,是33kDa,由Raji细胞分离的蛋白,与C1q的球部结合;C1q-R和gC1q-R在多种白细胞上同时表达,如多形核淋巴细胞,单核细胞,B和T淋巴细胞以及血小板,内皮细胞,纤维细胞,另外1种与C1q胶原样
In addition to its role in the traditional pathway of activating complement, C1q also plays an important role in promoting phagocytosis through its interaction with anti-target cell antibodies via the complement C3 receptor or its own receptor. There are two cell surface receptors that bind to human C1q: C1q-R, a 60 kDa glycoprotein that binds to the collagen-like region of C1q; gC1q-R, a 33 kDa protein that is isolated from Raji cells, binds to the ball of C1q ; C1q-R and gC1q-R expressed simultaneously on a variety of leukocytes, such as polymorphonuclear lymphocytes, monocytes, B and T lymphocytes, and platelets, endothelial cells, fibroblasts, the other one with C1q collagen-like