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本文对自1988年1月至1994年5月明确诊断为多器官功能衰竭(Multiple Organ Failure,MOF)的39例患者进行了回顾性总结,并分析了其发病原因、首发器官、各个脏器衰竭的发生频度、死亡原因和死亡率及其MOF的预防及治疗措施。分析结果显示,MOF的首发病因为严重感染、多发性创伤和急诊腹部大手术。其首发衰竭器官并不一定,资料分析以ARDS较为多见,其次有胃肠功能衰竭、急性肾功能衰竭,之所以存在如此差异,可能与导致MOF的病因不同有关。脏器衰竭的数目多为3—4个,四个以上器官发生序贯性衰竭很少。MOF的死亡原因为呼吸及循环衰竭,死亡率可达90％以上。由于对MOF的发病原因及发病机理目前尚不清楚,故一旦发病,治疗及其困难,所以MOF治疗的关键是预防为主,早期诊断,早期治疗。采取多种措施,及时处理有可能引起MOF的病因,如加强抗感染,对多发性创伤和大手术要彻底清除坏死组织,尽最大努力减少对组织的损伤,打断MOF发病的序贯过程,一旦发病,要给予强有力的呼吸及循环支持、营养支持并根据病人情况予以对症治疗。
This article retrospectively reviewed 39 patients diagnosed as Multiple Organ Failure (MOF) from January 1988 to May 1994 and analyzed their causes, primary organs, various organ failure Frequency of occurrence, causes of death and mortality and prevention and treatment of MOF. The analysis showed that the first cause of MOF was severe infection, multiple trauma and emergency abdominal surgery. The first failure of organ failure is not necessarily, data analysis is more common in ARDS, followed by gastrointestinal failure, acute renal failure, the existence of such differences may be related to the cause of MOF causes different. The number of organ failure, mostly 3-4, rarely occur in more than four organs of sequential failure. MOF causes respiratory and circulatory failure, the mortality rate of up to 90%. As the pathogenesis of MOF and the pathogenesis is not yet clear, so once the onset, treatment and its difficulties, so the key to the MOF treatment is prevention, early diagnosis and early treatment. Take a variety of measures to promptly deal with the possible causes of MOF, such as strengthening the anti-infection, multiple wounds and major surgery to completely remove necrotic tissue, make every effort to reduce the damage to the tissue, interrupt the sequential process MOF incidence, Once the disease, to give a strong respiratory and circulatory support, nutritional support and symptomatic treatment based on the patient’s condition.