A new lanthanide coordination polymer, [Ho(sba)(H_2O)_2(DMF)_2]×H_2O×DMF×Cl(1) based on the versatile ligand H2sba(H2sba = 4,4?-dicarboxybiphenyl sulfone), was prepared and characterized by single-crystal X-ray diffraction, elemental analysis, IR spectroscopy and thermogravimetric analysis. Single-crystal X-ray diffraction indicates that complex 1 belongs to the triclinic system, space group P1 with a = 10.6942(6), b = 11.8452(7), c = 13.1814(8) ?, α = 94.854(2), b = 96.649(2), γ = 91.663(2)o, V = 1651.30(17) ?3, Z = 2, Dc = 1.565 g·cm~(-3), μ = 2.597 mm~(-1), Mr = 777.98, F(000) = 780, the final R = 0.0446 and w R = 0.1116 with I > 2s(I). In the title complex, the Ho(III) ions exhibit 1D ∞-like double chains. The DMF molecules not only make the structure more stable, but also act as hydrogen bond acceptors making the 1D double chains into a three-dimensional(3D) supramolecular framework. In addition, the antifungal effects of the ligand, metal salt and Ho(III) complex have also been studied by the disc diffusion method against Colletotrichum gloeosporioides Penz. It was found that the antifungal activity of complex 1 was better than the corresponding ligand and the metal salt. Complex 1 has potential applications in the antifungal activity. A new lanthanide coordination polymer, [Ho (sba) (H_2O) _2 (DMF) _2] × H_2O × DMF × Cl (1) based on the versatile ligand H2sba (H2sba = 4,4 ~ -dicarboxybiphenyl sulfone), was prepared and single-crystal X-ray diffraction that belongs to the triclinic system, space group P1 with a = 10.6942 (6), b = 11.8452 Α = 94.854 (2), b = 96.649 (2), γ = 91.663 (2) o, V = 1651.30 (17)? 3, Z = 2 and Dc = 1.565 m = 2.597 mm -1, Mr = 777.98, F (000) = 780, the final R = 0.0446 and w R = 0.1116 with I> 2s (I) title complex, the Ho (III) ions exhibit 1D ∞-like double chains. The DMF molecules not only make the structure more stable, but also act as hydrogen bond acceptors making the 1D double chains into a three-dimensional (3D) supramolecular framework . In addition, the antifungal effects of the ligand, metal salt and Ho (III) complex have al so was studied by the disc diffusion method against Colletotrichum gloeosporioides Penz. It was found that the antifungal activity of complex 1 was better than the corresponding ligand and the metal salt. Complex 1 has potential applications in the antifungal activity.