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报告 41例颅内脊索瘤 (包括 2例软骨样脊索瘤 )的临床表现及组织病理和超微结构特点。脊索瘤的形态学特点为瘤细胞内有大量空泡及间质内的黏液基质 ;免疫组化对角蛋白、上皮膜抗原为阳性表达 ;电镜下可见桥粒、微绒毛以及粗面内质网包绕线粒体等特殊结构。软骨样脊索瘤的形态特点为出现非上皮组织来源的细胞并可见粗面内质网池中微管样结晶。研究结果证实脊索瘤中既有上皮组织分化的特点又有间叶组织的表现 ,还存在着具有多潜能分化的恶性干细胞群体。并对脊索瘤的超微结构分化状态与其恶性程度进行了探讨
Report of 41 cases of intracranial chordoma (including 2 cases of chondroid chordoma) clinical manifestations and histopathological and ultrastructural features. Morphology of chordoma was characterized by a large number of vacuoles and interstitial mucinous matrix in tumor cells. Immunohistochemistry showed positive expression of keratin and epithelial membrane antigen. Desmosome, microvilli and rough endoplasmic reticulum Envelops mitochondria and other special structures. Chondral chordoma is characterized by appearance of non-epithelial tissue-derived cells and microtubule-like crystals in the rough endoplasmic reticulum. The results confirmed that chordoma in both the characteristics of epithelial differentiation and the performance of mesenchymal tissue, there is also a multipotent differentiation of malignant stem cell populations. The ultrastructural differentiation of chordoma and its malignancy were also discussed