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目的了解资阳市近年手足口病病原学情况,为制定有效防控措施提供科学依据。方法按照中华人民共和国卫生部《手足口病预防控制指南》(2009版)要求,收集2010年-2012年全市县级以上医院部分临床诊断病人的咽拭子标本,用realtaime RT-PCR检测手足口病毒核酸。结果检测咽拭子标本617份,检出肠道病毒核酸阳性409例,阳性率66.3%,其中EV71病毒核酸阳性203例,CoxA16病毒核酸阳性119例,其他肠道病毒核酸阳性87例,构成比分别49.6%,29.1%21.3%。检出病毒核酸阳性标本的年龄最小7月,最大8岁,5岁以下儿童核酸阳性占94.9%。男女儿童核酸阳性率差异无统计学意义。结论资阳市手足口病毒主要感染5岁以下儿童,且各型病毒感染并存,尤以EV71型病毒感染为多。手足口病无特效治疗方法,加强预防控制显得尤为重要。
Objective To understand the etiopathogenisis of hand, foot and mouth disease in Ziyang in recent years and provide a scientific basis for making effective prevention and control measures. Methods According to the “Handbook of Prevention and Control of Hand-Foot-Mouth Disease” (2009 Edition) issued by the Ministry of Public Health of the People’s Republic of China, throat swab specimens of some clinically diagnosed patients from above-county level in the city from 2010 to 2012 were collected. Real-time RT- Viral nucleic acid. Results Six hundred and thirteen throat swab specimens were detected. The positive rate of enterovirus nucleic acid was 409 (66.3%), including 203 EV71 positive, 119 CoxA16 positive and 87 other enterovirus positive Respectively 49.6%, 29.1% and 21.3%. The virus-positive specimens were detected in the youngest months in July, up to 8 years old, children under 5 years of age nucleic acid positive 94.9%. There was no significant difference in the positive rate of nucleic acid between boys and girls. Conclusion Ziyang City hand-foot-mouth virus mainly infects children under 5 years of age, and various types of virus co-exist, especially EV71 virus infection. No special treatment of hand, foot and mouth disease, strengthen prevention and control is particularly important.