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目的 探讨充血性心力衰竭(CHF)患者血浆一氧化氮(NO)和内皮素(ET)含量变化及其关系。方法 检测65例CHF患者血浆NO和ET含量,另选30例健康体检者作为正常对照组。结果 CHF患者血浆NO和ET水平明显高于正常对照组(P<0.01)。且心衰程度越重,NO和ET水平越高。直线相关分析表明:NO与ET呈正相关(r=0.6457,P<0.001)。结论 血浆NO和ET水平增高是CHF病理生理特征之一。NO和ET共同参与CHF的发生发展过程。
Objective To investigate the changes of plasma nitric oxide (NO) and endothelin (ET) in patients with congestive heart failure (CHF) and their relationship. Methods The plasma levels of NO and ET in 65 patients with CHF were measured. Another 30 healthy subjects were selected as normal control group. Results The levels of plasma NO and ET in CHF patients were significantly higher than those in normal controls (P <0.01). And the more severe heart failure, NO and ET levels higher. Linear correlation analysis showed that there was a positive correlation between NO and ET (r = 0.6457, P <0.001). Conclusion The increase of plasma NO and ET levels is one of the pathophysiological features of CHF. NO and ET participate in the development of CHF.