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目的 :研究细胞黏附分子 E- CD在食管癌中的表达 ,探讨 E- CD表达与食管癌侵袭转移的关系。方法 :采用免疫组织化学 L SAB技术 ,检测 5 8例食管癌患者手术切除标本 E- CD蛋白表达 ,分析其表达与癌侵袭转移的关系。结果 :E- CD蛋白表达与食管癌患者年龄、性别及发生部位无关 (P>0 .0 5 ) ;与食管癌细胞分化程度相关 (P<0 .0 5 ) ,与管壁浸润深度、淋巴结转移密切相关 (P<0 .0 1)。结论 :E- CD蛋白表达减弱与食管癌侵袭转移潜能相关 ,可作为食管癌侵袭转移的生物学标志之一。
Objective: To study the expression of cell adhesion molecule E-CD in esophageal cancer and to explore the relationship between the expression of E-CD and the invasion and metastasis of esophageal cancer. Methods: Immunohistochemical L SAB technique was used to detect the expression of E-CD in surgical specimens from 58 esophageal cancer patients. The relationship between E-CD expression and invasion and metastasis was analyzed. Results: The expression of E-CD protein was not associated with the age, sex and location of esophageal cancer (P> 0.05), but correlated with the degree of differentiation of esophageal cancer cells (P <0.05) Metastasis was closely related (P <0.01). Conclusion: The decreased E-CD protein expression is associated with the invasion and metastasis of esophageal cancer and may be used as one of the biological markers for the invasion and metastasis of esophageal cancer.