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米托蒽醌（ｍｉｔｏｘａｎｔｒｏｎｅ，ＭＩＴ，ＤＨＡＱ）为１９８７年美国上市的有效抗癌药物，９０年代国内已生产并列为我国抗肿瘤类基本药物之一，为了解其致突变作用，我们进行了小鼠体内微核试验。结果表明国产ＭＩＴ６ｍｇ／ｋｇ、１２ｍｇ／ｋｇ、０６ｍｇ／ｋｇ
Mitoxantrone (MIT, DHAQ) is a potent anti-cancer drug marketed in the United States in 1987. It was produced in China in the 1990s as one of the basic anti-tumor drugs in our country. To understand its mutagenicity, we conducted a mouse In vivo micronucleus test. The results showed that domestic MIT6mg / kg, 1 2mg / kg, 0 6mg / kg