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目的探讨尿脱氧吡啶啉（ＤＰＤ）排泄率对糖尿病骨吸收的诊断意义。方法对４２例糖尿病患者和２１例正常健康人，用化学发光免疫分析法测定尿ＤＰＤ排泄率。结果糖尿病患者尿ＤＰＤ排泄率较正常组明显增高（Ｐ＜０．０１）；糖尿病绝经患者（１８例）尿排泄率（ＤＰＤ）较正常对照组绝经患者（７例）明显增高（Ｐ＜０．０５）。结论糖尿病患者骨吸收加快，尿ＤＰＤ排泄率是糖尿病骨吸收敏感指标，可作为糖尿病骨质疏松评估方法。
Objective To investigate the diagnostic value of urine deoxypyridinoline (DPD) excretion rate in the diagnosis of diabetic bone resorption. Methods The urine DPD excretion rate was measured by chemiluminescence immunoassay in 42 diabetic patients and 21 normal healthy subjects. Results The excretion rate of urinary DPD in diabetic patients was significantly higher than that in normal controls (P <0.01). Urinary excretion rate (DPD) in diabetic patients was significantly higher than that in normal controls (P <0.01). 05). Conclusion The accelerated bone resorption in diabetic patients and the excretion rate of urine DPD are sensitive indicators of bone resorption in diabetic patients, which can be used as a method for evaluating osteoporosis in diabetic patients.