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nm23-H 1是一种抑制转移的基因,其表达与某些恶性肿瘤的转移和预后呈负相关。结肠直肠癌的转移与nm23-H 1基因缺失或突变有关。本研究检测了手术切除的原发性结直肠癌标本中nm23-H 1免疫反应,以明确nm23-H 1的表达程度与肿瘤分级、分期和淋巴结转移是否相关。 1991年～1993年对100例相继入院的原发性结肠直肠癌患者做了根治性手术,切除全部区域淋巴结。按照世界卫生组织和国际防癌联合会(UICC)标准判定肿瘤分型、分级和分期。对每例患者平均检查了21个淋巴结,
nm23-H 1 is a gene that inhibits metastasis, and its expression is negatively correlated with the metastasis and prognosis of some malignant tumors. The metastasis of colorectal cancer is associated with the loss or mutation of the nm23-H1 gene. This study examined the nm23-H1 immune response in surgically resected primary colorectal cancer specimens to determine whether the expression of nm23-H1 is related to tumor grade, staging, and lymph node metastasis. From 1991 to 1993, 100 patients with primary colorectal cancer who had been admitted to the hospital had undergone radical surgery and removed all regional lymph nodes. According to the standards of the World Health Organization and the International Union Against Cancer (UICC), tumor classification, classification, and staging were determined. An average of 21 lymph nodes were examined for each patient.