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目的:探讨宫颈癌患者组织中c-met表达与宫颈癌淋巴结转移和复发的关系。方法:选取我院2005年6月至2010年6月间经病理确诊的患者120例。采用SP法检测c-met蛋白在宫颈癌组织中的表达,采用Pearson和Spearman相关性探讨c-met表达与宫颈癌患者临床特征的关系,采用COX回归模型探讨c-met表达与子宫颈癌转移与复发的的关系。结果:120例子宫颈癌患者中转移、复发或死亡者35例,相关性分析提示c-met蛋白水平与宫颈癌患者CA-125值、肿瘤的N分期、肿瘤侵犯深度成正相关,多因素分析提示:肿瘤分化程度(P=0.013)、c-met水平(P=0.02)、肿瘤侵犯深度(P=0.04)是宫颈癌患者转移或复发的独立危险因素。结论:宫颈癌组织中c-met表达阳性是宫颈癌患者转移、复发的独立危险因素。
Objective: To investigate the relationship between c-met expression and lymph node metastasis and recurrence of cervical cancer in patients with cervical cancer. Methods: A total of 120 patients diagnosed by pathology in our hospital from June 2005 to June 2010 were selected. The expression of c-met protein was detected by SP method in cervical cancer. Pearson and Spearman correlation was used to investigate the relationship between c-met expression and clinical features of cervical cancer. COX regression was used to investigate the relationship between c-met expression and cervical cancer metastasis Relationship with recurrence. Results: There were 35 cases of metastasis, recurrence or death in 120 cases of cervical cancer. Correlation analysis showed that the level of c-met protein was positively correlated with the CA-125 value, the N stage and the depth of tumor invasion in cervical cancer patients, and the multivariate analysis showed (P = 0.013), c-met level (P = 0.02) and tumor invasion depth (P = 0.04) were independent risk factors for the metastasis or recurrence of cervical cancer. Conclusion: The positive expression of c-met in cervical cancer is an independent risk factor for metastasis and recurrence of cervical cancer.