为选择利福平的最佳剂型,作者对利福平胶囊剂、片剂、栓剂、脂肪性基质口服制剂的生物利用度和对肝脏的毒性进行了实验。用体重13～15kg 的狗5条,禁食12小时后,投予相当于含利福平300mg 的口服制剂(用栓剂于前一天禁食),于0,0.5,1,2,3,4,5,6,7,8小时间隔 In order to select the best dosage form of rifampin, the authors tested the bioavailability of rifampicin capsules, tablets, suppositories, fatty oral formulations, and toxicity to the liver. Five dogs, weighing 13-15 kg, were fasted for 12 hours and then administered with an oral preparation equivalent to 300 mg containing rifampicin (fasted on the previous day with a suppository) at 0, 0.5, 1, 2, 3, 4 5,6,7,8 hours interval