丝虫三期蚴虫(L3)是其生活史中感染人体的重要形式。L3在蚊体内发育成熟,但直至蚊叮咬传播给哺乳动物宿主后才能进一步发育,提示虫体在该发育过程中受到宿主源性信号的调节。目前,有关与此相关的分子机制知之甚少。作者通过对Bp-cdd(编码胞嘧啶核苷脱氨酶)和Bp-S3基因表达模式的研究分析,以期发现可能触发感染后L3基因表达的哺乳动物特异性因素。 The third stage of filarial worms (L3) is an important form of infection of the human body in their life history. L3 matured in the mosquito but did not develop further until mosquito bites spread to mammalian hosts, suggesting that the parasites are regulated by host-derived signals during this development. At present, little is known about the molecular mechanisms involved in this. The authors analyzed the Bp-cdd (encoding cytidine deaminase) and Bp-S3 gene expression patterns in order to identify mammalian-specific factors that may trigger L3 gene expression after infection.