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自50年代Wilson和RumRe在男性不育症病人中发现抗精子抗体(ASAb)以来,免疫性不育越来越引起人们的重视,本文就男性免疫性不育症作一综述。一、男性生殖系统中的抗原 (一)精液中的抗原 1.血型抗原:人类精液中可有A、B、O血型抗原。其存在的意义尚不清,与自身致敏无关,可能导致精子的代谢损害。 2.HLA抗原:可能存在于精液。 3.抗原片段:精液中含有数十种抗原片段,其中大多数可以在血清中测出,如白蛋白、α-球蛋白、β-球蛋白,γ-球蛋
Since the discovery of anti-sperm antibody (ASAb) by Wilson and RumRe in male infertility patients in the 1950s, immunological infertility has drawn more and more attention. This article reviews the male infertility. First, the antigen in the male reproductive system (A) of the antigen in the semen 1. Blood group antigen: human semen can have A, B, O blood group antigen. The significance of its existence is unclear, has nothing to do with its own sensitization, may lead to metabolic damage of sperm. 2.HLA antigen: may exist in the semen. 3. Antigen fragments: Semen contains dozens of antigen fragments, most of which can be measured in serum, such as albumin, α-globulin, β-globulin, γ-egg