论文部分内容阅读
目的探讨孕中期联合AFP、Free β-HCG、uE_3检测在产前筛查中的临床意义。方法采用时间分辨免疫荧光法对2825例孕中期孕妇血清的AFP、Free β-HCG和uE_3浓度进行联合检测,结合孕周、体重、年龄等因素进行风险评估,并与羊水染色体分析结果进行对照。结果 2825例孕妇中共筛查出高危妊娠133例,其中21-三体高风险124例,18-三体高风险者9例,两者筛查高风险率分别为4.71%、0.32%。经染色体培养核型分析,共确诊染色体异常患者11例,其中21-三体患儿2例,18-三体患儿1例,其他染色体异常8例。结论孕中期联合AFP、Free β-HCG、uE_3检测可有效检出常见染色体异常患儿,具有重要的产前筛查意义。
Objective To investigate the clinical significance of pre-pregnancy screening combined with AFP, Free β-HCG and uE_3 in the second trimester of pregnancy. Methods The serum levels of AFP, Free β-HCG and uE_3 in 2825 pregnant women of the second trimester were detected by time-resolved immunofluorescence method. The risk factors were estimated by the combination of gestational age, body weight, age and other factors. The results were compared with the results of amniotic fluid chromosome analysis. Results A total of 2825 pregnant women were screened out for 133 high-risk pregnancies. Among them, 124 were high risk of trisomy 21 and 9 were high risk of trisomy 18. The high risk of screening was 4.71% and 0.32% respectively. Chromosome culture karyotype analysis, a total of 11 patients diagnosed chromosomal abnormalities, including 21 cases of trisomy 21, trisomy 18 cases 1, other 8 cases of chromosomal abnormalities. Conclusion The combination of AFP, Free β-HCG and uE_3 in the second trimester can detect common chromosomal abnormalities in children with prenatal screening.